Available by Prescription Only.

Low Dose Naltrexone (LDN) capsules are a compounded pharmaceutical prepared by a licensed pharmacist to meet specific dosage requirements not available in commercially manufactured forms. While Naltrexone is FDA-approved at higher doses (typically 50mg to 100mg) for treating alcohol and opioid dependence, LDN utilizes significantly smaller amounts—usually ranging from 0.5mg to 4.5mg.

The mechanism of LDN is believed to involve a brief, temporary blockade of opioid receptors. This "rebound effect" signals the body to increase the production of endogenous opioids (endorphins) and upregulate opioid receptors. Additionally, LDN is studied for its ability to reduce glial cell activation in the central nervous system, which may help decrease neuroinflammation. Because of these unique properties, practitioners often prescribe LDN as a complementary therapy for conditions such as fibromyalgia, Crohn’s disease, multiple sclerosis, and various autoimmune disorders. Because it is compounded, capsules can be formulated without common fillers like lactose or gluten to accommodate patients with specific allergies.

• Rx Only: This is a prescription medication and must be used under the direct supervision of a licensed healthcare provider.
• FDA Disclaimer: This compounded medication has not been evaluated by the FDA for safety or efficacy in this specific dosage form. Compounded medications are not FDA-approved.
• Opioid Interaction: Do not take LDN if you are currently taking narcotic pain medications (opioids), as it can trigger acute withdrawal symptoms.
• Surgery: Discontinue use at least 48 to 72 hours prior to any scheduled surgery where opioid anesthesia may be required.
• Pregnancy/Nursing: Consult your physician if you are pregnant, planning to become pregnant, or breastfeeding.
• Side Effects: While generally well-tolerated, some patients report vivid dreams, insomnia, or mild digestive upset during the initial titration phase.

• How to Use: Follow your prescriber’s exact titration schedule. LDN is most commonly taken once daily at bedtime to align with the body's natural endorphin production cycle, though it can be taken in the morning if insomnia occurs.
• Storage: Store capsules in their original light-resistant container at controlled room temperature (between 15°C and 30°C).
• Environment: Keep away from excessive heat, moisture, and direct sunlight. Do not store in a bathroom cabinet where humidity is high.
• Safety: Keep out of the reach of children and pets.
• Expiration: Discard any unused medication after the "Beyond Use Date" (BUD) listed on the pharmacy label.